Psychometric performance of a generic walking scale walk12g in multiple sclerosis and parkinsons disease article pdf available in journal of neurology 2594. Multiple sclerosis and demyelinating disorders articles. The multiple sclerosis walking scale12 msws12 is a multiitem rating scale used to assess the perspectives of patients about the impact of ms on their walking ability. To date, there is limited evidence regarding the validity of pdds scores, despite its sound conceptual development and broad inclusion in ms research. Combined training improves walking mobility in persons. The sample included 269 individuals with a definite diagnosis of relapsingremitting ms who. The 12item multiple sclerosis walking scale msws 12 what does this author special investigating alternative medicine but in many cases most patients to ever be truly better improving the patient has been brought on by facial movements through even with associated with multiple sclerosis before contract. Progressive resistance training prt has proven to be a promising intervention showing a positive effect on muscle strength. Six ms outpatient clinics across italy enrolled subjects between june 20 and. We examined the quality of the msws 12 using an item response theory model, the graded response model grm. Pdf italian validation of the 12item multiple sclerosis. Pooled data were analyzed from 2 phase iii randomized placebocontrolled clinical trials of dalfampridine in multiple sclerosis ms n 533. It consists of 12 questions concerning the limitations to walking due to ms during the past 2 weeks. Value of gait analysis for measuring disease severity.
The aim of this study is to examine the psychometric properties of the walk12g in people with multiple sclerosis ms and parkinsons disease pd. Pdf mapping the 12item multiple sclerosis walking scale to. Pdf multiple sclerosis walking scale12, translation. Validation of patient determined disease steps pdds. Specific symptoms can include double vision, blindness in one. The aim of this study was to crossculturally adapt and validate the msws 12 for the italian population with ms. Confirming the validity and responsiveness of the multiple. In this study, we used data from clinical trials of dalfampridine fampridine outside the united states to reexamine the clinical meaningfulness of timed 25foot walk t25fw changes. The aim was to investigate the effects of a groupbased balance exercise program targeting core stability, dual tasking, and sensory strategies coduse on balance, postural sway, walking, perceived walking limitations, and balance confidence. Pdf mapping the 12item multiple sclerosis walking scale. Background walking capacity tests are commonly used to evaluate interventions aiming at reducing walking impairment in people with multiple sclerosis pwms.
Evaluation of the sixminute walk in multiple sclerosis subjects and healthy controls. The impact of fatigue on patients with multiple sclerosis. The msws12v1 was completed at screening and all scheduled and unscheduled study visits. The multiple sclerosis walking scale msws12 is the predominant patientreported measure of multiple sclerosis ms elated walking ability, yet it had not been analyzed using item response theory irt, the emerging standard for patientreported outcome pro validation. Evaluating walking in patients with multiple sclerosis. A more precise tool for assessing walking function in ms. Patientreported outcomes are also useful to inform disease severity.
One hundred fortynine patients in the community and 53 hospital outpatients with ms completed the msws12 and other outcome measures. This study, namely, step it up will compare the effect of an exercise plus social cognitive theory sctbased. Lower walking speed was observed in 85% of the patients. In a version 2, three items are scored, and nine items are. The multiple sclerosis severity score msss is another scale, which is obtained by normalizing the edss score for disease duration 5. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Mapping the 12item multiple sclerosis walking scale to the euroqol 5dimension index measure in north american multiple sclerosis patients. Draft qualification opinion of multiple sclerosis clinical outcome. Journal of rehabilitation medicine aerobic intensity and.
Currently, there are few established pharmacogenetic predictors of response to treatment in multiple sclerosis ms patients. Cognitive processing speed has minimal influence on the construct validity of multiple sclerosis walking scale12 scores. Multiple sclerosis walking scale12, translation, adaptation and validation for the persian language population. Feb 03, 2016 the 12 item multiple sclerosis walking scale msws 12 is a patientreported outcome that assesses the impact of walking impairment in people with ms. We examined the quality of the msws12 using an item response theory model, the graded response model grm. Identifying an important change threshold for the multiple. The psychometric properties of the msws12 were excellent, and in. The multiple sclerosis walking scale12 msws12 is a 12item selfreport.
Pdf mapping of multiple sclerosis walking scale msws12 to. Factors for lower walking speed in persons with multiple sclerosis. Twelve item ms walking scale msws12 sailing sclerosis. Multiple sclerosis or ms is a chronic, often disabling disease that causes damage in the central nervous system brain and spinal cord. The scale has not been independently validated for use in differing ms populations. This study examined the hypothesis that accelerometer movement counts represent a measure of both physical activity and walking mobility in individuals with ms. Gp6 rs2304166 polymorphism is associated with response to natalizumab in multiple sclerosis patients. A separate approval was obtained from the same irb for the acquisition of the. The disease is thought to be triggered in a genetically susceptible individual by a. The patient determined disease steps pdds is a promising patientreported outcome pro of disability in multiple sclerosis ms. Approximately 400,000 people in the united states have multiple sclerosis ms. Motion sensors such as accelerometers have been recognized as an ideal measure of physical activity in persons with ms.
Pdf background although multinational clinical trials frequently use patient reported outcomes to. The 12item ms walking scale msws12 assesses patients measurement of walking quality. The multiple sclerosis walking scale is a selfassessment scale which measures the impact of ms on walking. Multiple sclerosis impact scale msis29 the following questions ask for your views about the impact of ms on your daytoday life during the past two weeks for each statement, please circle the one number that best describes your situation please answer all questions in the past two weeks, how much has. The original scoring provides options 15 for each item, with 1 meaning no limitation and 5 meaning extreme limitation on the gaitrelated item. It is often characterized by relapsing episodes of neurologic. Pdf testing patientreported outcome measurement equivalence. Six ms outpatient clinics across italy enrolled subjects between june 20 and december 20. This study examined the validity of the pdds based on 1 the association with expanded disability status scale. Validity of minimal clinically important difference values.
Original research paper development of a gait module to. Multiple sclerosis is an unpredictable and potentially disabling disease of the central nervous system, which interrupts the flow of information within the brain, and between the brain and body. The multiple sclerosis walking scale12 msws12 measures walking ability from the patients perspective. Pdf psychometric performance of a generic walking scale. Behaviour change interventions aim to promote longterm positive lifestyle change. Mapping the 12item multiple sclerosis walking scale to. Multiple sclerosis and progressive resistance training.
Multiple measures of mobility were used, walking speed was assessed using the timed 25foot walk t25fw. Multiple sclerosis the most common genital malignancy of western countries points to a deficiency in b12 can multiple sclerosis walking scale12 impair the concern and confusion revolved in triggering the disease and this symptoms that last over a period of time it is important that they conditions. However, these effects have not been maintained in the longterm. Multiple sclerosis walking scale12 version 1 msws12v1 the msws12v1 is a 12item questionnaire that asks subjects to rate, on a 5point scale from 1not at all to 5extremely, their msrelated mobility limitations during the preceding 2 weeks. Italian validation of the 12item multiple sclerosis walking. The 6mwt is feasible and tolerated in subjects with ms, including those in the upper. Objective to map the 12item multiple sclerosis walking scale msws12 onto the. This study aimed to profile gait pathology in gaitimpaired patients with ms using comprehensive 3d. The higher the scorepercentage, the greater the perceived impact ms is having on walking ability. Introduction multiple sclerosis ms is characterized by a demyelination that results in reduced conductivity in the somatosensory nervous system, decreased muscle strength, vestibular alteration, and severe fatigue. Profiling walking dysfunction in multiple sclerosis. Crosscultural adaptation and validation of the 12item multiple sclerosis walking scale msws12 for the brazilian population. Multiple sclerosis walking scale12 and oxygen cost of. Commonly used second line treatments include natalizumab that has proven to.
The 12item multiple sclerosis walking scale msws12 is a new, selfrated measure of walking ability. Exercise has consistently yielded shortterm, positive effects on health outcomes in people with multiple sclerosis ms. Core muscle characteristics during walking of patients. In contrast to the edss, scoring of the ai is dependent on the need for an. Sep 29, 2011 the walk12g was adapted from the 12item multiple sclerosis walking scale as a generic patientreported rating scale for walking difficulties in everyday life. An equation for mapping the msws 12 to the eq5d was previously developed and validated using a north american research committee on ms narcoms registry cohort. Twelve item ms walking scale msws 12 graph patient progress over time twelve item ms walking scale use the graphs below to plot the percentage score from the questionnaire at each visit. Evaluation of the multiple sclerosis walking scale12 msws. Italian validation of the 12item multiple sclerosis. The 12item multiple sclerosis walking scale msws12 is a patientreported outcome measure that assesses patients perception of the impact of multiple sclerosis ms on walking ability, but cannot be used in costeffectiveness or costutility analyses which require a healthutility score to calculate qualityadjusted lifeyears. Each item can be answered with 5 options, with 1 meaning no limitation and 5 extreme limitation.
A total of 625 unique dutch multiple sclerosis ms patients were included. Timed 25foot walk and patient selfreport 12item multiple sclerosis walking scale have. Walking limitations are among the most visible manifestations of multiple. The aim of this study was to examine the reliability and validity of the msws 12 in persian speaking patients with ms. The aim of this study was to crossculturally adapt and validate the msws12 for the italian population with ms. A change will be indicated by a reduction or increase. Gait impairment is commonly in people with multiple sclerosis ms. Gait dysfunction is a common and relevant symptom in multiple sclerosis ms. The multiple sclerosis walking scale 12 msws 12 is a valid patientreported questionnaire rating walking ability in pwms.
Walking impairment is a common marker of disease progression in individuals with multiple sclerosis ms. However, their ecological validity has recently been questioned. Fisk jd, pontefract a, ritvo pg, archibald cj, murray tj. Multiple sclerosis impact scale 29 items msis incorporating all these dimensions. Balance and walking impairments are frequent in people with multiple sclerosis ms. The 12item multiple sclerosis walking scale msws12 is a selfreport measure of the impact of ms on the individuals walking ability. I physical therapist and masters student in health sciences.
Multiple sclerosis walking scale 12 version 1 msws12v1 the msws12v1 is a 12 item questionnaire that asks subjects to rate, on a 5point scale from 1not at all to 5extremely, their msrelated mobility limitations during the preceding 2 weeks. T1 validity of minimal clinically important difference values for the multiple sclerosis walking scale12. The aim of this study was to examine the reliability and validity of the msws12 in persian speaking patients with ms. Motor fatigue measurement by distanceinduced slow down of walking speed in multiple sclerosis. This study provides a validation of accelerometer output based on associations with expanded disability status scale edss, patient determined disease steps pdds scale, and multiple sclerosis walking scale.
Eight patients 4 men with relapsingremitting ms aged 44. Mapping the 12item multiple sclerosis walking scale to the euroqol. The 12item multiple sclerosis walking scale msws12 is a patientreported outcome that assesses the impact of walking impairment in people with ms. Ecological validity of walking capacity tests following. The multiple sclerosis walking scale 12item msws12 is a pro measure that is widely used to address this need. Phanba r, calay p, grodent p, delrue g, lommers e, delvaux v, et al. Montreal a modified version of the sixminute walk test 6mwt may measure walking disability in patients with multiple sclerosis ms more precisely than the tests currently used for this purpose, according to research presented at the 25th annual meeting of the consortium of multiple sclerosis centers. Multiple sclerosis ms is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
The multiple sclerosis walking scale 12 msws 12 is a multiitem rating scale used to assess the perspectives of patients about the impact of ms on their walking ability. Multiple sclerosis ms is an autoimmune and inflammatory demyelinating disease of the central nervous system, affecting 0. Hobart jc, riazi a, lamping dl, fitzpatrick r, thompson aj. Mapping of multiple sclerosis walking scale msws12 to five. The aim of the present study was to investigate the ecological validity of the 2 and 6minutes walking tests 2mwt and 6mwt and the timed 25foot walk t25fw after 28. Thirteen participants with significant disability due to ms expanded disability status scale range 4. Using the fatigue severity scale to inform healthcare decision. The multiple sclerosis walking scale 12 msws 12 measures walking ability from the patients perspective. Evaluation of the multiple sclerosis walking scale12. Abstractthe purpose of this study was to investigate core muscle characteristics during walking in patients with multiple sclerosis ms. Symptoms may be mild, such as numbness in the arms and legs, or severe, such as paralysis or loss of vision.
Mapping the 12item multiple sclerosis walking scale to the. Accelerometry as a measure of walking behavior in multiple. There are many measures of walking impairment that have been included in research and clinical practice such as the expanded disability status scale edss, timed walk tests e. Multiple sclerosis walking scale12, translation, adaptation. Influence of spasticity on mobility and balance in persons.